Based on oxidative stress of dinotefuran in SH-SY5Y cells:Chirality in energy metabolism
简介：Dinotefuran is a widely used neonicotinoid insecticide with a chiral structure,and its potential neurotoxic mech-anism has not been fully elucidated.This study revealed that S-dinotefuran showed more significant inhibitory effect than R-dinotefuran and rac-(±)-dinotefuran on various mitochondrial damage indexes of SH-SY5Y.This discovery provides a new perspective for the study of the toxicity mechanism of dinotefuran.S-dinotefuran ex-erts cytotoxicity by suppressing the cellular antioxidant system,disrupting mitochondrial membrane potential,and interfering with energy metabolism pathways.The primary mechanism involves strong inhibition of mito-chondrial respiratory chain complex activity,leading to impaired Adenosine triphosphate(ATP)synthesis and abnormal alterations in energy-related metabolites in SH-SY5Y cells.展开
学者：JingtongYuYuanTangChangLiuAiqiFengQuanZhangMeirongZHAO
关键词：Neonicotinoid pesticidesDinotefuranchiralityEnergy metabolismoxidative stressSH-SY5Y cells
在线出版日期：2026-05-11 （网站首发日期）
